Ren Kagome was a famous human Bounty Hunter from Hades who was known for seducing and assassinating several figures within Hades' government. She was one of the most demented, twisted, and cunning individuals within even Hades who had sired several children: that she physically and mentally abused on a daily basis. This resulted in them either running away, cursing her existence, or eventually killing her in her sleep.
Ren means "lotus" and "love", whilst Kagome can mean "a basket full of holes", "a pregnant woman", or even "a caged bird".
Ren's surname, Kagome is also a reference to "Kagome Kagome" a Japanese children's game that is known for having multiple theories about the deeper and more sinister meanings of it's lyrics. That range from forced prostituion, a pregnant woman forced down the stairs leading to a miscarriage, a convinct who's disemebodied head gazes at his own body, or even the Illuminati.